Cinchonain Ia inhibits uric acid reabsorption by binding to the TRP-459 residue of the GLUT9 protein - PubMed
4 hours ago
- #GLUT9
- #Hyperuricemia
- #Cinchonain Ia
- Cinchonain Ia, found in Polygonum capitatum aqueous extract, binds to the TRP-459 residue of the GLUT9 protein.
- This binding inhibits GLUT9 expression, reducing uric acid reabsorption and lowering serum uric acid levels.
- The extract alleviates kidney injury and oxidative stress without harming liver function in hyperuricemia models.
- It also modulates gut microbiota and renal metabolites, increasing beneficial bacteria and reducing harmful ones.
- Overexpression of GLUT9 reverses the protective effects of Cinchonain Ia on inflammation and tissue damage.