Spatial omics study reveals molecular-cellular dynamics of tumor ecosystem in esophageal squamous-cell carcinoma initiation and progression - PubMed
4 days ago
- #spatial-omics
- #ESCC
- #tumor-microenvironment
- Spatial omics study on 32 tissue samples from 18 ESCC patients reveals molecular-cellular dynamics during tumor evolution.
- Early ESCC stages show coordinated regulation of epidermal development and keratinocyte differentiation, with increased B cells and decreased T cells.
- Late ESCC stages exhibit continuous upregulation of the PI3K/AKT pathway and dysregulation of tertiary lymphoid structures.
- O-GlcNAc transferase gene activation in late stages correlates with poor prognosis; its knockdown inhibits ESCC cell migration and invasion.
- Findings verified by multiplex immunofluorescence, providing insights for precision therapeutics in ESCC.