Hyper-oncotic albumin administration reduces mortality in acute Respiratory Distress Syndrome compared to crystalloid: a systematic review and meta-analysis - PubMed
5 hours ago
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- #albumin
- #ARDS
- Hyper-oncotic albumin administration reduces mortality in ARDS compared to crystalloids.
- Meta-analysis included 5 studies (3 RCTs, 2 NRSs) with 28-day mortality as the primary endpoint.
- Overall mortality was lower in the albumin group (33.2%) vs. crystalloid group (44.9%).
- Hyper-oncotic albumin showed reduced mortality in NRSs but not in RCTs.
- Iso-oncotic albumin showed no significant benefit in mortality reduction.
- Albumin improved oxygenation on the first and second days post-administration.
- Trial sequential analysis suggests a need for more high-quality RCTs to confirm findings.