USP20, a Super-enhancer Regulated Gene, Promotes Acute Myeloid Leukemia Progression through CTNNB1 Deubiquitination - PubMed
2 days ago
- #CTNNB1
- #AML
- #USP20
- USP20 is identified as a super-enhancer regulated gene frequently associated with AML.
- USP20 overexpression in AML correlates with adverse prognosis.
- Knockdown of USP20 induces apoptosis and suppresses AML cell proliferation.
- USP20 inhibitor AS1517499 shows anti-leukemic effects with low toxicity.
- USP20 stabilizes CTNNB1 via deubiquitination, promoting AML progression.
- USP20 and CTNNB1 co-localize and regulate target genes in AML.
- Targeting the SE-USP20-CTNNB1 axis presents a promising therapeutic strategy.