Prognostic Significance of Pretreatment 18F-FDG PET/CT in Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis - PubMed
3 hours ago
- #Prognostic Significance
- #Hepatocellular Carcinoma
- #18F-FDG PET/CT
- Pretreatment 18F-FDG PET/CT positivity in HCC is observed in 30.8% of patients.
- Increased FDG uptake correlates with poorer overall survival (HR 2.05), recurrence-free survival (HR 3.18), and progression-free survival (HR 1.64).
- The prognostic significance holds across curative and non-curative treatments and various PET/CT parameters (e.g., SUVmax, tumor-to-liver ratio).
- The meta-analysis included 59 studies (8,585 patients), highlighting consistent associations between FDG activity and adverse clinical outcomes.
- Findings support further investigation into 18F-FDG PET/CT for risk stratification and patient selection in HCC management.