Multi-omics analysis and preliminary experimental validation of acetyl tributyl citrate (ATBC) promoting bladder cancer progression via the AKR1B1/EMT axis - PubMed
5 hours ago
- #Molecular Docking
- #AKR1B1
- #Bladder Cancer
- ATBC, a widely used plasticizer, is linked to cancer risks, particularly bladder cancer (BCa).
- The study used computational and experimental methods to explore ATBC's molecular targets and mechanisms in BCa.
- ATBC promoted BCa cell proliferation and migration, as shown by functional experiments.
- 461 potential ATBC binding targets were identified, with 142 linked to BCa.
- AKR1B1 was identified as a key target with strong binding affinity to ATBC.
- Multi-omics analyses showed AKR1B1 upregulation in BCa, correlating with advanced disease and poor prognosis.
- ATBC promotes epithelial-mesenchymal transition (EMT) in BCa cells via AKR1B1.
- Knockdown of AKR1B1 inhibited ATBC-induced EMT and migration in BCa cells.
- Findings provide insights into plasticizer environmental toxicology and potential therapeutic strategies.