Immune-microbiome coordination defines interferon setpoints in healthy humans - PubMed
2 days ago
- #multi-omic
- #interferon
- #immune-microbiome
- Human immune systems vary significantly, largely due to non-genetic factors.
- The gut microbiome plays a crucial role in shaping the immune system.
- Multi-omic profiling of 110 healthy participants revealed coordinated variation between microbiome and immune states.
- Interferon response was identified as one of the most variable immune features in healthy individuals.
- Microbiome composition, pathways, and stool metabolites varied alongside interferon response pathways.
- Longitudinal data showed significant stability of these parameters within individuals over time.
- The study provides extensive data to examine immune-microbiome relationships in healthy individuals.
- Findings may help understand disease susceptibility and therapy responses.