Colorectal cancer pathogenesis, oncogenic signaling networks and targeted therapeutic advances - PubMed
4 hours ago
- #Targeted Therapy
- #Colorectal Cancer
- #Oncogenic Signaling
- Colorectal cancer (CRC) is the third most diagnosed malignancy and second leading cause of cancer-related deaths globally.
- Malignant transformation in CRC arises from dysregulation of intracellular signaling networks.
- Targeted therapies have improved patient survival but molecular complexity limits overall prognosis.
- The review highlights core signaling pathways in CRC initiation and progression, focusing on molecular hallmarks.
- Current targeted agents, their mechanisms, clinical effects, and limitations are summarized.
- Advances in immune checkpoint inhibitors (ICIs) and tumor microenvironment understanding are influencing clinical guidelines and revealing new targets.
- Insights into oncogenic pathways are guiding novel treatments and identifying pharmacological intervention points.
- The review supports the design of precise, personalized therapeutic strategies to improve CRC prognosis.