Oxidative Stress and Hormone-Regulated Dermal Papilla Cell-Targeted Nanomodulators: Reverse Cellular Senescence for Androgenetic Alopecia Therapy - PubMed
5 hours ago
- #Androgenetic Alopecia
- #Hair Regeneration
- #Nanotechnology
- Androgenetic alopecia (AGA) is characterized by dermal papilla cell (DPC) senescence due to dihydrotestosterone accumulation and oxidative stress.
- Current AGA treatments face challenges like poor hair follicle targeting and limited efficacy from single-pathway interventions.
- A novel DPC-targeted nanomodulator (L-LP-Fi/CeNP) combines finasteride and cerium oxide nanoparticles to inhibit dihydrotestosterone and scavenge reactive oxygen species.
- The nanomodulator enhances cutaneous penetration and prolongs drug retention by targeting the DPC-specific leptin receptor.
- In AGA mouse models, L-LP-Fi/CeNPs showed hair regenerative efficacy comparable or superior to minoxidil, the current standard treatment.
- This study presents a promising dual-pathway therapeutic strategy for AGA using nanotechnology and small-molecule drug synergism.