Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection - PubMed
5 hours ago
- #cytotoxicity
- #γδ T cells
- #host defense
- Two distinct subsets of γδIELs identified: stem-like (CD160+TCF1+BCL6+) and effector-like (granzymeB+BLIMP1+).
- Stem-like γδIELs differentiate into effector-like cells in response to microbiota and pathogen infection.
- IL-12, IL-15, and TCR signaling activate STAT4-BLIMP1 pathway for effector differentiation and cytotoxic function.
- TCF1 deletion reduces stem-like γδIELs, while BCL6 deficiency increases effector-like γδIELs.
- BLIMP1 absence abolishes effector-like γδIELs and impairs pathogen clearance, highlighting its critical role in host defense.