Repurposing COVID-19 (and other) mRNA vaccines to boost cancer immunotherapy efficacy: mechanistic insights and future directions - PubMed
4 hours ago
- #immune checkpoint inhibitors
- #cancer immunotherapy
- #mRNA vaccines
- COVID-19 mRNA vaccines can reshape the tumor microenvironment to enhance immune checkpoint inhibitor efficacy.
- The mechanism involves innate immune responses overcoming tumor immune evasion and activating polyclonal CD8+ T cells.
- Repurposing existing mRNA vaccines with ICIs offers a clinically feasible and rapidly translatable approach to cancer immunotherapy.