PRMT3-Mediated Arginine Methylation Stabilizes PCSK9 to Promote Aortic Valve Calcification - PubMed
4 days ago
- #aortic valve calcification
- #PRMT3
- #PCSK9
- PRMT3 expression is upregulated during aortic valve calcification.
- RUNX2 recruits P300 to promote PRMT3 expression via histone H3 lysine 27 acetylation.
- Prmt3 haploinsufficiency reduces aortic valve calcification in high-cholesterol diet-fed ApoE-/- mice.
- Pharmacologic PRMT3 inhibition and degradation show anticalcific effects.
- PRMT3 promotes osteogenic differentiation of human valvular interstitial cells.
- PRMT3 catalyzes asymmetric dimethylation of PCSK9 at arginine 582, stabilizing PCSK9.
- Methylation prevents E3 ligase CHIP binding, reducing PCSK9 ubiquitination and degradation.
- PRMT3-mediated arginine methylation links lipid-osteogenic coupling in valve calcification.