Primary Aldosteronism: CXCR4- and FAP-Targeted PET/MR for Adrenal-Cardiac Axis - PubMed
5 hours ago
- #Primary Aldosteronism
- #PET/MR Imaging
- #Adrenal-Cardiac Axis
- Primary aldosteronism (PA) involves excess cardiovascular risk not fully explained by hemodynamic load.
- The study used CXCR4-targeted PET/MR and FAP-targeted PET/MR to assess the adrenal-cardiac axis in PA.
- Adrenal CXCR4 signal correlated with aldosterone burden and adverse left ventricular remodeling, independent of blood pressure.
- Myocardial FAPI uptake was higher in PA patients (55%), especially APA (71.4%), compared to controls (0%).
- Adrenal CXCR4 signal correlated with myocardial FAPI activity and cardiac remodeling markers linked to aldosterone levels.
- After adrenalectomy, myocardial FAPI uptake decreased significantly in APA patients, but cardiac function markers did not change.
- The findings show CXCR4-FAP-mediated adrenal-cardiac cross-talk in PA, indicating myocardial fibroblast activation beyond blood pressure effects.
- FAPI PET revealed more severe myocardial activation in APA, reversible post-adrenalectomy, highlighting early diagnosis and surgical intervention.