TET2-CHIP: From Mutation to Malady - PubMed
4 hours ago
- #Clonal Hematopoiesis
- #TET2
- #Cardiovascular Disease
- TET2 is a common driver gene in clonal hematopoiesis of intermediate potential (CHIP).
- Loss of TET2 function impairs hematopoietic stem cell differentiation and alters immune cell function.
- TET2-CHIP is strongly associated with cardiovascular disease and chronic inflammation.
- Factors like aging, lifestyle, metabolic disorders, and infections influence TET2-mutant clone expansion.
- Emerging studies explore therapeutic strategies for TET2-CHIP-associated cardiovascular disease.