Double-stranded RNA and ROS scavenging nanoplatform for modulating skin inflammation - PubMed
3 hours ago
- #skin inflammation
- #nanomedicine
- #drug delivery
- A new nanoplatform using cerium-doped polyoxometalate (Mo90Ce10) simultaneously targets double-stranded RNA (dsRNA) and reactive oxygen species (ROS) to modulate skin inflammation.
- In vitro, Mo90Ce10 scavenges ROS and suppresses type I interferon responses by directly binding dsRNA via hydrogen bonds, showing higher activity than its structural template.
- In vivo, Mo90Ce10 reduces disease severity, dsRNA-induced inflammation, ROS levels, and neutrophil infiltration in skin inflammatory diseases like psoriasis and atopic dermatitis.
- A transdermal delivery platform is developed by complexing Mo90Ce10 with cationic peptide TD-1 and co-loading methotrexate, enhancing drug penetration and therapeutic efficacy while lowering recurrence.