Reciprocal regulation of fibroblast-macrophage equilibrium governs skin integrity - PubMed
5 hours ago
- #skin integrity
- #CSF1-CSF1R axis
- #fibroblast-macrophage crosstalk
- Fibroblast-macrophage crosstalk is crucial for skin integrity.
- Fibroblast-derived CSF1 supports macrophages in specific tissues.
- Depletion of fibroblasts or loss of growth factors affects skin macrophage populations.
- Conditional deletion of Csf1 in Dpt+ fibroblasts reduces CD64+ and CD11c+ macrophages, impairing wound healing.
- Reduced macrophage abundance disrupts fibroblast cell cycle regulation, metabolism, and immune signaling.
- Increased fibroblast abundance confirms a reciprocal relationship between fibroblasts and macrophages.
- In systemic sclerosis, elevated fibroblast-derived CSF1 and increased macrophage abundance correlate with disease severity.
- The CSF1-CSF1R axis is implicated in pathology.
- Findings reveal bidirectional interplay advancing understanding of skin homeostasis and immune regulation.