Epigenetic dysregulation and microenvironment remodeling in pancreatic cancer - PubMed
5 hours ago
- #Pancreatic cancer
- #Tumor microenvironment
- #Epigenetics
- Epigenetic dysregulation and microenvironment remodeling are key features of pancreatic ductal adenocarcinoma (PDAC).
- Mutations in epigenetic regulators and nonmutational reprogramming driven by oncogenic and metabolic stresses contribute to PDAC.
- Recent advances in low-input epigenomics and single-cell technologies highlight the role of epigenetics in cellular plasticity, stromal reprogramming, immune evasion, and therapy resistance.
- Epigenetic mechanisms play stage- and context-dependent roles in tumor progression, tumor microenvironment crosstalk, and metabolic adaptation.
- Emerging therapeutic strategies target epigenetic vulnerabilities in PDAC.
- Cutting-edge epigenomic profiling and functional studies aim to translate epigenetic discoveries into clinical strategies against PDAC.