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Artificial Sweeteners and Gut Microbiota: Mechanistic Insights and Implications for Metabolic Health - PubMed

2 days ago
  • #gut microbiota
  • #artificial sweeteners
  • #metabolic health
  • Artificial sweeteners (ASs) are widely used sugar substitutes but are not metabolically inert.
  • AS exposure alters gut microbiota composition, diversity, and short-chain fatty acid (SCFA) production.
  • These alterations affect glucose homeostasis, insulin sensitivity, and energy metabolism.
  • Mechanisms include modulation of nutrient-sensing receptors and intracellular signaling pathways.
  • Human responses are highly individualized and dose-dependent, showing significant variability.
  • Findings have implications for dietary guidance, especially for those with metabolic disorders.