Structure of Crimean-Congo haemorrhagic fever virus RNA polymerase - PubMed
5 hours ago
- #CCHFV
- #cryo-EM
- #RNA polymerase
- Crimean-Congo haemorrhagic fever virus (CCHFV) is highly pathogenic with no approved antivirals.
- Cryo-EM structures of CCHFV L protein (RNA polymerase) in apo and RNA-bound states at 2.62 Å and 2.53 Å resolution.
- The structures reveal the polymerase core's PA-, PB1-, and PB2-like domains, promoter recognition mechanism, and RNA-induced conformational changes.
- These insights provide a structural basis for understanding nairovirus replication and developing polymerase inhibitors.