Sevoflurane protects against testicular ischaemia-reperfusion injury in rats - PubMed
6 hours ago
- #Sevoflurane
- #Testicular Ischemia-Reperfusion Injury
- #ERK1/2 Signaling
- Sevoflurane, an inhaled anesthetic, protects against testicular ischemia-reperfusion injury in rats.
- It reduces acute injury markers like edema, oxidative stress, inflammation, and apoptosis.
- Long-term benefits include less testicular atrophy and improved sperm count, motility, and spermatogenesis.
- Protection involves ERK1/2 activation in the RISK pathway, and is blocked by the inhibitor U0126.
- Findings suggest sevoflurane as a novel strategy to mitigate complications after testicular torsion surgery.