Fto-mediated m6A demethylation of Lox drives atrial fibrosis and promotes atrial fibrillation in a murine model of hyperthyroidism - PubMed
14 hours ago
- #Atrial Fibrillation
- #Hyperthyroidism
- #RNA Methylation
- Hyperthyroidism is a risk factor for atrial fibrillation (AF) and is linked to increased AF recurrence and larger low-voltage areas (LVA).
- Fto-mediated m6A demethylation of Lox mRNA increases Lox expression, leading to atrial fibrosis and higher AF susceptibility in hyperthyroidism.
- In a murine model, Fto upregulation promoted AF, while its deletion reduced T4-induced atrial fibrosis and AF.
- Lox inhibition with BAPN suppressed fibrosis and AF inducibility, suggesting potential therapeutic targets for hyperthyroidism-associated AF.
- The study highlights the role of Fto-m6A-Lox pathway in atrial arrhythmogenicity and proposes it as a novel therapeutic target.