Farnesylation-driven KRAS phase separation promotes colon tumor growth - PubMed
4 hours ago
- #KRAS
- #Phase Separation
- #Colon Cancer
- Farnesylation of KRAS at C185 drives its liquid-liquid phase separation (LLPS), forming cytoplasmic condensates associated with advanced colon cancer and poor outcomes.
- KRAS condensates promote clustering and interaction with RCE1, enhancing KRAS processing, membrane translocation, and signaling to accelerate tumor growth, especially under growth factor stimulation.
- Statins like pitavastatin, by inhibiting farnesylation, disrupt KRAS LLPS, suppress colon cancer growth, and boost the efficacy of G12Ci therapy, revealing a therapeutic target.