Activation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure - PubMed
5 hours ago
- #mitochondrial dysfunction
- #heart failure
- #IRF3 activation
- Activation of IRF3 in cardiomyocytes leads to mitochondrial dysfunction and heart failure.
- IRF3 activation represses Ppargc1α, impairing oxidative phosphorylation and metabolic flux.
- Cardiomyocyte-specific IRF3 deficiency improves contractile function post-ischemia.
- Restoring Ppargc1α expression mitigates IRF3-induced cardiac dysfunction by enhancing fatty acid oxidation.
- IRF3 serves as a transcriptional link between cardiac inflammation and metabolic dysfunction.