Dissecting the immunosuppressive microenvironment of LAMA3 + malignant cells and SPP1 + macrophages in esophageal squamous cell carcinoma using single-cell and spatial transcriptomics - PubMed
5 hours ago
- #single-cell transcriptomics
- #immunosuppressive microenvironment
- #esophageal squamous cell carcinoma
- Study focuses on the immunosuppressive microenvironment in esophageal squamous cell carcinoma (ESCC).
- Utilizes single-cell and spatial transcriptomics to analyze LAMA3+ malignant cells and SPP1+ macrophages.
- No ethical approval required as the study did not involve human participants or animals.
- Authors declare no competing interests.
- References include studies on tumor heterogeneity, spatial transcriptomics, and single-cell transcriptional landscapes.
- Mentions global burden and temporal trends in esophageal cancer incidence and mortality.