Safety of Acetaminophen Use in Pregnancy: Review of Existing Evidence - PubMed
a day ago
- #pregnancy
- #acetaminophen
- #neurodevelopmental disorders
- Acetaminophen is the most widely used antipyretic and analgesic medication during pregnancy.
- Recent concerns have linked prenatal acetaminophen exposure to adverse neurodevelopmental outcomes like ASD and ADHD, reproductive issues, and endocrine abnormalities.
- Systematic reviews and meta-analyses indicate small increased risks for ASD and ADHD, which are minimal in sibling-controlled analyses.
- Evidence for male reproductive effects, such as cryptorchidism and reduced anogenital distance, is inconsistent.
- Major biases in observational studies include confounding by indication, recall bias, and information bias.
- The case for causality is weak, and current evidence does not justify a change in practice.
- International regulatory and obstetrical bodies endorse judicious use of acetaminophen as a preferred analgesic and antipyretic in pregnancy.