Insights into the therapeutic strategies for aging and aging-associated diseases - PubMed
4 hours ago
- #senolytics
- #aging therapeutics
- #AI in longevity
- Aging is a complex process leading to functional decline and increased risk of age-related diseases like neurodegeneration and cardiovascular issues.
- Therapeutic strategies target aging hallmarks, including cellular senescence, metabolic dysfunction, epigenetic alterations, and mitochondrial impairment.
- Key interventions include senolytics (e.g., dasatinib + quercetin), senomorphics (e.g., rapamycin), and senoreversion via epigenetic reprogramming.
- Metabolic interventions, such as caloric restriction mimetics (e.g., spermidine), improve mitochondrial function, autophagy, and energy metabolism, extending lifespan in preclinical models.
- Artificial intelligence (AI) accelerates discovery by integrating multiomics data, predicting compounds, identifying biomarkers, and enabling personalized interventions.
- Challenges include target specificity, off-target effects, and clinical translation, but interdisciplinary strategies signal a transformative era in precision longevity medicine.