Human receptive endometrial assembloid for deciphering the implantation window - PubMed
17 hours ago
- #endometrial assembloid
- #implantation window
- #reproductive biology
- Researchers developed a human window-of-implantation (WOI) endometrial assembloid system that mimics the receptive endometrium.
- The assembloid reproduces structural features like pinopodes and cilia, and molecular traits of mid-secretory endometrium.
- It shows hormone responsiveness, enhanced mitochondrial function, increased ciliary activity, epithelial-mesenchymal transition, and potential for embryo implantation.
- WOI assembloids serve as a platform to study endometrial receptivity, maternal-fetal interactions, and related pathologies.