The Infrapatellar Fat Pad in Osteoarthritis: From Pathophysiology to a Novel Therapeutic Target - PubMed
5 hours ago
- #regenerative medicine
- #infrapatellar fat pad
- #osteoarthritis
- Osteoarthritis (OA) is a prevalent degenerative joint disease affecting millions globally.
- The infrapatellar fat pad (IPFP) contains diverse cell types, including mesenchymal stem cells (MSCs) and extracellular vesicles (EVs), with potential in regenerative medicine.
- IPFP actively secretes adipokines (e.g., leptin, adiponectin) and cytokines, and has a rich neural network involved in knee pain perception.
- IPFP and synovium interact closely with each other and cartilage, forming an integrated unit.
- IPFP is emerging as a biomarker in imaging applications.
- The decision to resect or preserve IPFP in clinical practice remains controversial.
- This article reviews IPFP's role in OA mechanisms and its clinical applications for OA treatment.