hUCMSC mitochondrial EVs confer neuroprotection after ischemia by Tom1l2-mediated mitochondrial fusion and Crls1-cardiolipin axis reprogramming - PubMed
4 days ago
- #neuroprotection
- #ischemic stroke
- #mitochondrial repair
- hUCMSC mitochondrial EVs (Mito-EVs) provide neuroprotection after ischemic stroke by transferring functional mitochondria to damaged neurons.
- The process involves Tom1l2-mediated mitochondrial fusion, restoring mitochondrial membrane potential and function.
- Mito-EVs upregulate cardiolipin synthase 1 (CRLS1), preserving mitochondrial membrane integrity and stabilizing respiratory chain complexes.
- This mitochondrial repair reduces reactive oxygen species, suppresses pyroptosis, and promotes neuronal metabolic and functional recovery.
- The Tom1l2-Crls1 axis is identified as a key mediator in mitochondrial repair, offering a potential therapeutic strategy for ischemic stroke.