FUBL-3/FUBP1 mediates mitochondrial stress-induced chromatin remodeling and longevity - PubMed
4 hours ago
- #Mitochondrial Stress
- #Chromatin Remodeling
- #Longevity
- The study identifies FUBL-3/FUBP1 as a key regulator linking mitochondrial stress to chromatin remodeling and longevity in C. elegans.
- Under mitochondrial stress, FUBL-3 moves to intestinal nuclei, where it drives nucleosome remodeling, chromatin condensation, and activates the mitochondrial unfolded protein response (UPRmt).
- Loss of fubl-3 disrupts chromatin compaction and prevents stress-induced lifespan extension, while its overexpression can restructure chromatin, trigger UPRmt, and extend lifespan.
- Human FUBP1 can functionally replace FUBL-3 in worms and mediates chromatin remodeling in mammalian cells under mitochondrial stress.
- FUBP1 binds to promoters of genes involved in proteostasis and mitochondrial quality control, supporting its role in nuclear adaptation to stress.