Demographic and genetic factors shape the epitope specificity of the human antibody repertoire against viruses - PubMed
5 days ago
- #antibody repertoire
- #genetic factors
- #viral epitopes
- Demographic and genetic factors influence the specificity of human antibody responses to viruses.
- Age, sex, and continent of birth affect which viral epitopes are targeted by antibodies.
- Antibodies against rapidly evolving influenza A epitopes decrease with age, while reactivity to conserved epitopes increases.
- Genetic variants at HLA, FUT2, IGH, and IGK loci are associated with antibody responses to 34 viruses.
- Some genetic associations identified may increase the risk of autoimmune diseases.
- The study provides a resource for understanding antibody-mediated immunity and optimizing vaccine strategies.