Integrated Multi-omic Profiling Identifies BRD8/EP400 as a Pivotal Chromatin Module Mediating Anti-HER2 Response in HR+/HER2+ Breast Cancer - PubMed
5 hours ago
- #multi-omic profiling
- #HER2 therapy resistance
- #BRD8/EP400 chromatin module
- BRD8, part of the EP400 complex, is identified as crucial for ER/HER2 signaling crosstalk in HR+/HER2+ breast cancer.
- Anti-HER2 treatment increases BRD8 expression; its depletion disrupts ER-HER2 interaction and boosts drug sensitivity.
- BRD8 regulates ER-dependent and independent growth pathways and helps overcome therapy resistance by modulating chromatin accessibility.
- A 3-gene BRD8 signature predicts anti-HER2 therapy response, positioning BRD8 as both a biomarker and therapeutic target.