The Fatty Acid Transporter CD36 Mediates Uptake, Biodistribution, and Cardioprotection by Small Extracellular Vesicles From HEK293 Cells - PubMed
7 hours ago
- #CD36
- #cardioprotection
- #extracellular vesicles
- The study investigates the role of the fatty acid transporter CD36 in the uptake, biodistribution, and cardioprotective effects of small extracellular vesicles (sEVs) derived from HEK293 cells.
- sEVs, labeled with NanoLuc, showed preferential uptake by cardiac endothelial cells over cardiomyocytes and accumulated mainly in the lungs, liver, and spleen in healthy mice.
- Administration of sEVs post-cardiac ischemia and reperfusion (IR) injury significantly reduced infarct size from 58% to 36%, demonstrating their therapeutic potential in myocardial infarction (MI).
- Inhibition of CD36 with sulfosuccinimidyl oleate impaired sEV uptake and abolished their cardioprotective effects, identifying CD36 as a key mediator in sEV function.
- The findings suggest that HEK293-derived sEVs could be a promising therapeutic approach for MI, with CD36 playing a crucial role in their mechanism of action.