GIPC1 governed ferroptosis by regulating DECR1-modulating lipid homeostasis during dilated cardiomyopathy (DCM) - PubMed
5 days ago
- #cardiomyopathy
- #lipid homeostasis
- #ferroptosis
- GIPC1 is significantly downregulated in cardiac tissues from DCM patients and DOX-induced DCM models.
- GIPC1 deficiency disrupts mitochondrial fatty acid metabolism, increases PUFA-PLs, and promotes ferroptosis in cardiomyocytes.
- GIPC1 interacts with DECR1 via its PDZ domain, facilitating actin-dependent transport of DECR1 into mitochondria.
- GIPC1/DECR1 axis maintains redox homeostasis and suppresses ferroptosis, highlighting a potential therapeutic strategy for DCM.
- DECR1 overexpression rescues GIPC1 ablation-induced ferroptosis by balancing redox homeostasis.