Apoptotic Bodies in Kidney Disease: Orchestrators of Inflammation, Fibrosis, and Repair - PubMed
12 hours ago
- #apoptotic bodies
- #fibrosis
- #kidney disease
- Apoptotic bodies are membrane-bound vesicles from programmed cell death, now seen as dynamic mediators in kidney disease.
- In healthy kidneys, apoptotic bodies are efficiently cleared to maintain tissue homeostasis.
- In acute kidney injury (AKI), impaired clearance of apoptotic bodies can amplify inflammation and dysfunction, while efficient removal promotes repair.
- Chronic kidney disease (CKD) sees persistent apoptosis and defective clearance, leading to interstitial accumulation of apoptotic bodies that drive fibrosis.
- Apoptotic bodies from vascular smooth muscle cells contribute to vascular calcification in CKD.
- Apoptotic bodies regulate injury, inflammation, fibrosis, regeneration, and vascular pathology, offering potential for new biomarkers and therapies.