Alzheimer's Aβ catalyzes Tau phase separation and aggregation via early nanocluster solubilization - PubMed
14 hours ago
- #Alzheimer's disease
- #Amyloid-beta
- #Tau protein
- Aβ40 enhances Tau phase separation and is recruited into Tau condensates.
- Aβ40 alters condensate properties, accelerates maturation, and promotes Tau amyloid fibril formation.
- Aβ40 increases Tau-mediated cytotoxicity.
- Aβ40 transiently solubilizes Tau nanoclusters into smaller species before condensate formation.
- Early interactions between Aβ40 and Tau are non-specific and mediated by Tau repeat domains.
- Aβ acts as a catalyst for Tau condensation and fibrillation, promoting pathological aggregation.