Monocytes Defined by Platelet Interactions and Oxidative Stress Signaling Underlie HIV-Associated Atherosclerosis - PubMed
5 hours ago
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- #monocyte
- #atherosclerosis
- Monocytes contribute to atherosclerosis by migrating into inflamed endothelium and differentiating into lipid-laden macrophages.
- Chronic inflammation in people living with HIV increases atherosclerosis risk, but the role of specific monocyte subsets remains unclear.
- Seven monocyte clusters were identified, including a subset characterized by platelet-monocyte complexes.
- Platelet-monocyte complex-derived macrophages promote endothelial dysfunction and adopt a profibrotic cytokine profile.
- CD14+ monocytes from HIV+ groups show enhanced ROS-NRF2 pathway activities, indicating oxidative stress priming.
- Two monocyte clusters contribute independently to vascular immune dysregulation in people living with HIV.
- These mechanisms may accelerate atherosclerosis development in HIV, even without traditional cardiovascular risk factors.