Association of blood levels of forever plastics with lung cancer mortality among ever smokers in the Prostate Lung Colorectal and Ovarian (PLCO) cohort study - PubMed
11 hours ago
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- Study evaluates the association between circulating levels of plastic-associated chemicals (microplastics, PFAS, and plasticizers) and lung cancer mortality among smokers in the PLCO cohort.
- Higher levels of PFOS, PFHA, and mono-iso-nonyl-phthalate were linked to increased lung cancer mortality risk but not incidence.
- A PFAP model (PFOS + PFHA + mono-iso-nonyl-phthalate) predicted higher lung cancer mortality risk, with the highest quantile showing significantly elevated hazard ratios.
- The PFAP model remained an independent predictor of lung cancer mortality across various demographic and clinical subgroups.
- Elevated levels of these chemicals were consistently associated with increased lung cancer mortality among smokers in the PLCO cohort.