Atractylenolide I alleviates bleomycin-induced idiopathic pulmonary fibrosis via regulating HIF-1α to suppress oxidative stress and endoplasmic reticulum stress - PubMed
4 days ago
- #Idiopathic pulmonary fibrosis
- #Atractylenolide I
- #HIF-1α
- Atractylenolide I (ATL-I) alleviates bleomycin-induced idiopathic pulmonary fibrosis (IPF) by regulating HIF-1α.
- ATL-I reduces oxidative stress and endoplasmic reticulum (ER) stress in fibroblasts, inhibiting their activation.
- Mechanistically, ATL-I binds directly to HIF-1α, promoting its degradation and lowering reactive oxygen species (ROS) levels.
- The study used a bleomycin-induced mouse model and in vitro assays to demonstrate ATL-I's antifibrotic effects.
- Network pharmacology identified core targets and pathways of ATL-I, supporting its therapeutic potential for IPF.