Autoimmunity in IgA nephropathy - PubMed
5 hours ago
- #IgA nephropathy
- #autoimmunity
- #glomerulonephritis
- IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide.
- The pathogenesis involves a multi-hit hypothesis with galactose-deficient IgA1 (Gd-IgA1) as a central driver.
- Recent advances have led to revisions in the KDIGO Clinical Practice Guideline.
- Multiple therapeutic agents are under development, with some already approved as of 2025.
- A key unresolved question is why Gd-IgA1-containing immune complexes deposit selectively in the glomerular mesangial region.
- Recent discoveries include IgA-type anti-mesangial cell antibodies (IgA-MESCA) targeting β2-spectrin and CBX3.
- The review discusses evidence on autoantibodies in IgAN and their potential role in pathogenesis.