Acetylsalicylic acid improves outcome after acute myocardial infarction by reduction of thromboinflammation - PubMed
4 days ago
- #Thromboinflammation
- #Acetylsalicylic acid
- #Myocardial infarction
- Acetylsalicylic acid (ASA) improves outcomes after acute myocardial infarction (AMI) by reducing thromboinflammation.
- ASA reduces infarct size, improves cardiac function, and remodeling in both pre- and intra-ischemia treatments in a murine AMI model.
- The cardioprotective effects of ASA are dependent on platelets and neutrophils, and are mediated through CD40L pathways.
- ASA-pretreated STEMI patients showed improved outcomes, including reduced mortality, compared to ASA-naive patients.
- Existing ASA therapy has pleiotropic effects in reducing thromboinflammation and improving AMI outcomes, independent of preventing ischemia recurrence.