Association of White Matter Hyperintensities, Regional Brain Glucose Metabolism, and Cognitive Impairment in Aβ-Negative Patients - PubMed
6 hours ago
- #Brain Glucose Metabolism
- #White Matter Hyperintensities
- #Cognitive Impairment
- Study examines the relationship between periventricular white matter hyperintensities (PWMHs), regional brain glucose hypometabolism, and cognitive impairment in Aβ-negative patients.
- 141 Aβ-negative patients with mild cognitive impairment (MCI) and 83 normal controls (NCs) underwent 18F-FDG PET, MRI, and cognitive testing.
- Greater PWMH burden correlated with lower glucose metabolism, particularly in the posterior cingulate cortex (PCC).
- PWMHs were associated with lower executive function, verbal memory, and visual memory scores.
- Path analysis showed PWMHs affect executive function indirectly via hypometabolism in the frontal lobe and PCC, while directly impacting memory.
- Findings suggest combining 18F-FDG PET with MRI could improve diagnostic and therapeutic approaches for vascular cognitive impairment.