Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis - PubMed
4 hours ago
- #L1 retrotransposition
- #chromosomal instability
- #tumorigenesis
- LINE-1 (L1) retrotransposition generates somatic genomic variation in human cancer.
- Long-read sequencing of 10 tumors with high retrotransposition activity revealed over 6,000 somatic events.
- L1-mediated reciprocal translocations frequently occur due to two concurrent L1 retrotransposition events on non-homologous chromosomes.
- Retrotransposon-mediated rearrangements occur at a frequency of one event per 60 somatic retrotranspositions.
- Molecular timing analyses show these events arise early in tumorigenesis, making L1 activity an early driver of chromosomal instability.
- L1 significantly contributes to cancer genome evolution in certain tumors.