Spatial metabolomics and transcriptomics reveal the metabolic-immune niche associated with renal fibrosis in hyperuricemia - PubMed
6 hours ago
- #Renal fibrosis
- #Spatial multi-omics
- #Hyperuricemic nephropathy
- Spatial metabolomics and transcriptomics reveal a metabolic signature of hypoxic adaptation in hyperuricemic kidneys, characterized by anaerobic glycolysis and impaired mitochondrial function.
- The study identifies selective expansion and spatial co-localization of Cxcl14+ fibroblasts and Vim+ macrophages, forming a metabolic-immune niche.
- Computational analyses suggest a self-reinforcing feedback circuit: macrophage-derived TNF activates fibroblasts via NF-κB signaling, while fibroblast-secreted TGF-β maintains macrophages in a profibrotic state.
- Targeting hypoxia-dependent fibroblast-macrophage crosstalk is proposed as a potential therapeutic strategy to limit renal fibrosis in hyperuricemic nephropathy.