IL-4 treatment induces apoptosis of blood monocytes and proliferation of recruited injury-associated macrophages to resolve liver injury - PubMed
5 hours ago
- #liver-repair
- #macrophages
- #IL-4
- IL-4 treatment shifts Ly6Chi monocytes to monocyte-derived macrophages (MoMFs) in liver injury.
- IL-4 induces apoptosis of monocytes and proliferation of MoMFs, aiding liver repair.
- Single-cell RNA sequencing shows pro-reparative gene signatures in expanded MoMFs.
- CCR2-deficient mice show no enhanced repair, indicating MoMFs' role in IL-4-mediated healing.
- IL-4 alters myeloid cell composition and function to resolve liver injury.