The prevalence and clinical significance of clonal monocytosis - PubMed
4 days ago
- #clonal monocytosis
- #myeloid neoplasia
- #machine learning
- The study introduces terms CMUS and CCMUS for clonal hematopoiesis with monocytosis not meeting CMML criteria.
- Analyzed 431,531 UK Biobank participants to assess prevalence and outcomes of CMUS/CCMUS.
- Found CMUS and CCMUS are high-risk, linked to myeloid neoplasia, cardiovascular, and renal diseases.
- Proposed sex-specific monocyte thresholds and excluding isolated DNMT3A mutations to strengthen MN association.
- Developed MoSAIC, a machine learning tool to predict SRSF2 mutations in monocytosis cases using blood counts.
- Validated findings in a Danish cohort of 625,328 primary care patients.
- Concluded CMUS and CCMUS are high-risk states needing refined diagnostic criteria.