Immune, molecular and genetic profiles of gastric signet ring cell carcinoma: Recent progress and future challenges - PubMed
5 hours ago
- #gastric cancer
- #immunotherapy
- #tumor microenvironment
- Gastric signet ring cell carcinoma (GSRCC) is a type of gastric cancer common in young women and is considered a subtype of diffuse gastric cancer.
- GSRCC originates from MUC5AC-/MUC6- pre-pit cells in the proliferative area of the gastric gland and exhibits high plasticity influenced by extracellular Wnt signaling.
- The tumor immune microenvironment in GSRCC is in a relatively 'quiescent' state with reduced T cell activation and increased regulatory T cell infiltration.
- Poor response to immunotherapy in GSRCC patients is associated with low CXCL13 production from exhausted CD8+ T cells and a lack of mature tertiary lymphoid structures.
- Future therapeutic strategies may focus on enhancing CXCL13 production by CD8+ T cells to improve immunotherapy responses in GSRCC.