Sex Differences in P-Tau217, Tau Aggregation, and Cognitive Decline - PubMed
6 days ago
- #Alzheimer's disease
- #sex differences
- #tau pathology
- Women with high amyloid-β (Aβ) levels show higher insoluble tau burden and accumulation compared to men.
- Plasma phosphorylated tau 217 (p-tau217) levels are higher in women at elevated Aβ Centiloid levels.
- Sex differences in p-tau217 levels influence tau aggregation, measured via PET, in a sex-specific manner.
- Women exhibit greater tau deposition and accumulation at higher p-tau217 levels compared to men.
- Higher p-tau217 levels in women correlate with faster cognitive decline relative to men.
- Findings suggest sex-specific responses in tau pathology, impacting Alzheimer's disease diagnostics and therapeutics.