Senescence in cancer: Hallmarks, paradoxes, and therapeutic promise - PubMed
6 hours ago
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- #cancer
- Cellular senescence is a conserved stress-responsive program characterized by durable proliferative arrest and extensive biological remodeling.
- It is a pleiotropic and heterogeneous process with roles in development, tissue repair, immune surveillance, tumor suppression, aging, fibrosis, and cancer progression.
- Senescence's molecular features, functional outputs, and physiological consequences vary across cell types, tissues, and stimuli, making it challenging to define operationally.
- In cancer, senescence influences tumor initiation, evolution, and therapeutic response through both cell-intrinsic and microenvironmental mechanisms.
- Emerging therapeutic strategies aim to modulate senescence, presenting both opportunities and unresolved challenges for precision intervention.