Lipedema and Dynapenia: Inflammatory Myosteatosis as a Mechanistic Link Between Tissue Expansion and Muscle Dysfunction - PubMed
5 hours ago
- #lipedema
- #dynapenia
- #myosteatosis
- Lipedema is a chronic, progressive adipose tissue disorder with disproportionate fat accumulation, pain, and edema.
- Functional impairment in advanced lipedema cannot be explained by adipose pathology alone.
- Inflammatory myosteatosis is proposed as a link between lipedema progression and dynapenia (muscle weakness).
- Chronic adipose inflammation and microvascular dysfunction may lead to ectopic lipid deposition in skeletal muscle.
- This causes mitochondrial dysfunction, oxidative stress, and reduced muscle contractile efficiency.
- Lipedema-related muscle dysfunction differs from obesity-associated dynapenia due to localized adipose-muscle inflammatory crosstalk.
- Advanced lipedema is reframed as a disorder of coupled adipose-muscle dysfunction rather than isolated fat excess.
- Future studies should focus on muscle quality, mitochondrial function, and inflammatory signaling to understand functional decline.